Scientific-Medical-Clinical Test Results
Table of Content
- Clinical study University Hospital Antwerp Belgium
- Clinical study Cuneo Italy - introduction
- Summary & example practical of scientific and medical test - Belgium
- Medical study Bonn Germany
- Medical study HS Denmark
- Medical study L. Pasteur Lille - Uni Hospital Brussels Belgium
- Scientific study University Leuven Belgium
- Scientific study VITO - Belgo Nucleaire Belgium
Clinical Study: Aspergillus spp. Air Contamination during renovation works
Neonatal Intensive Care Unit - University Hospital Antwerpen Belgium
Presented at:
- European Congress for clinical Microbiology and Infectious Diseases / Stockholm
- International Congress for Paediatrics and Immunology / Brussels
- Published Journal of Hospital Infections of the Hospital Infection Society
- Published in Noso Info and the Epidemiologisch Bulletin van de Vlaamse Gemeenschap
Renovation Works in Operational NICU - SEVERE CONTAMINATION CONDITIONS -
Renovation works are well known for creating high risk airborne infections. There is an unavoidable increase in the circulation of dust, which is an excellent vehicle for transporting fungi, moulds and spores such as Aspergillus. Adjacent graphics show figures during 10 months renovation in the N.I.C.U. which was already equipped with a closed HVAC-system equipped with hepa filters.
Despite these existing hepa filters, and the known preventive measures, like installation of physical barriers (plastic sealing, partitions and intermediate spaces), Aspergillus spp. Concentrations were unacceptably high. Installation of MedicCleanAir® - Infection Control Units proved severe reduction of airborne contamination.
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NORMAL WORKING CONDITIONS WITHIN THE HOSPITAL ENVIRONMENT - Haematology / Oncology department of S. Croce Hospital Cuneo Italy
Clinical, laboratory and microbiological survey during 2 years:
Prevention of Invasive Aspergillosis in immune-compromised patients by high-efficiency air filtration MedicCleanAir® - devices. - Istituto Tumori Università di Genova and Istituto di Igiene Universita di Genova - Italy
As prior medical studies have proven, Hospital Infections occur mainly within the hospital itself and rarely come from outside. As air is the main 'transporter' of all airborne contamination this study proves that air quality is of utmost importance to prevent contamination from going from one department to another.
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COST - RELATING STUDY ON THE IMPLEMENTATION OF MEDICCLEANAIR DEVICES - Haematology department of S. Croce Hospital Cuneo Italy.
Study (2 years) on MedicCleanAir® devices for air filtration, a low-cost very effective method of managing ambient Aspergillus spp colonization. - Haematology Department and Hygiene and National Cancer Institute of Genoa Medical School Italy.
Every hospital is bounded by economic resources. Practically every hospital has money problems. It is therefore of great importance to determine at what level MedicCleanAir® Mobile Hepa Units may not only contribute to the human but also to economic situation of the hospital itself.
Above mentioned study certifies that the investment in MedicCleanAir gives a yearly return of more than 8 times the initial investment itself (saving of € 161.000/year). Moreover, the study did not take into account that by excluding infections - and therefore reducing lay days/hospital bed days - the waiting lists are reduced, more patients could be handled and thus increasing the hospital general turnover. Nor did they take into account that doctors could increase their performances (more operations) and complete departments could handle more patients due to that fact.
Although the study was directed only to Aspergillus infections, the MedicCleanAir® Mobile Hepa Units adsorb all other contaminants as well. Because of the above, the amount gained by implementation is exceeding far more the amount of 8 times return on its investment. (Could easily be 12 times/year)
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Summary & Example of a practical scientific and medical test
Location
Luik - Liège Belgium, department of haematology/oncology. Click here to receive more detailed information regarding the hospital)
General
These tests were carried out during 2 days during which particle counts and CFU counts were performed.
The variables such as air ventilation systems, meteorological conditions, passage of visitors, conditions in the department itself etc. have not been taken into account. These are usually necessary to be able to make a firm clinical study. Nevertheless, the figures show the impact of the MedicCleanAir® Mobile Hepa Units and are to be considered as significant.
Introduction
The results of the 2 tests (particles and CFU count) show already the following points of view:
- that the level of contamination of the ambient air is higher than ever expected,
- that probably not only the rooms where tests were performed are contaminated, but the complete department and beyond are contaminated as well.
- that the preventive measures regarding air quality will have to be taken seriously in order to improve the present air quality and hygiene level of the department.
Situation
Date: October 2005
Dimensions of the room: D346cm x L500cm x H260/360cm + bath room D180cm x L210cm x H260cm
Total Cubic metres: 60 m3
Measurement Technique particles: MetOne type 228 number of particles per cft - >= 0.3 µm
Measurement Technique CFU's: voir annexe Dpt. Hygiène
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to receive more detailed information.
Good to know:
- the number of particles in the rooms vary between 2.4 mio et 4.000.000/ cft³
- the number of particles outside the hospital amounted to 8.400.000/cft³ on October 6th 2005
- room temperature varied between 25°C and 27.5°C
- humidity in the room varied between 42% et 60%
Results
| 05/10/05 14H30 | 05/10/05 15H15 | 05/10/05 20H | 06/10/05 8H | 06/10/05 12H | Réd. % | |||||
| Particules | 2.400.000 | > | 1.900.000 | > | 1.500.000 | > | 620.000 | > | 1.000.000 | 60à75% |
| Micrococcus | 14 CFU/m³ | > | 8 CFU/m³ | > | 0 CFU/m³ | > | 7 CFU/m³ | > | 2 CFU/m³ | 85à100% |
| Bacillus | 4 CFU/m³ | > | 1 CFU/m³ | > | 3 CFU/m³ | > | 2 CFU/m³ | > | 0 CFU/m³ | 100% |
| Staphylococ | 126 CFU/m³ | > | 82 CFU/m³ | > | 63 CFU/m³ | > | 61 CFU/m³ | > | 24 CFU/m³ | 81% |
| Streptococcus | --- | > | --- | > | 2 CFU/m³ | > | --- | > | 2 CFU/m³ | ? |
Scheme
Remarks
The figures give a very good idea of the existing situation and level of contamination in that haematology / oncology department; counts are rather high. To be correct it is to be said that these tests cannot be medically supported for 100% as too many variables were not taken into account.
Nevertheless, MedicCleanAir® Mobile Hepa Units were able to reduce the contamination - CFU level as well as particle level - with 60 up to 100%.
However, the contamination level should be < 1 cfu/m³ within the patient's room and MedicCleanAir® therefore advises following steps to be taken:
Recommendations
- One MedicCleanAir® Pro Unit in each room: operational level 1 during nigh time, level 2 during daytime and level 4 when there is no patient in the room,
- Two MedicCleanAir® Pro Units in the corridors - operational level 2 - always.
- One MedicCleanAir® Pro Unit at the entrance of the department, with prefilters attached to the Unit, and equipped with
the key remote control device - unit to be operational at level 3.
Additionally, we advise to put automatic door closures to the double entrance door. These doors should stay closed as much as possible. - One MedicCleanAir® Pro Unit in the visitor's elevator compartment - entrance, to be installed on a shelf close to the entrance of the department, equipped with the key remote control device. - Unit to be operational on level 3. The access (double doors) to the department should be equipped with these automatic closing features as well.
- The access to the children's playground of the adjacent department should stay closed at all times. If not, doors should be equipped with the automatic closing features, and we advise to install one MedicCleanAir® Pro Unit in the airlock between the two departments.
- Perform a periodical particle and CFU- count.
Medical Study 2005 - CFU count of mainly concentrations of Aspergillosis in the department of Paediatric / Oncology of a German University Hospital.
Click here to receive more detailed information regarding the hospital.
Situation
- The hospital is located on the outside limits of the city, centralized in a green park.
- The HVAC system of the hospital was able to reduce the spores coming from outside and amounting to 168 cfu/m3 to 16 cfu/m3 in the corridors and patient's rooms of the hospital.
- These figures are still unacceptable for Paediatric / Oncology rooms.
- Technical features of the rooms: 1 patient per room - dimensions: maximum 5 x 4 x 2.8 metres.
- The window of the rooms is often opened (min 2x per day during 0.5 hours)
Installation
- 1x MedicCleanAir® Mobile Hepa Unit near the window of the patient's room..
- 1x MedicCleanAir® Mobile Hepa Unit near the entrance of the patient's room.
Results
MedicCleanAir® Mobile Hepa Units were able to reduce the amount of CFU in the patient's room to zero!
HS HOSPITAL - DENMARK
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Operating Theatre - Orthopaedics / Day Surgery, equipped with a normal integrated fixed ventilation system.
Objectives:
- To establish the development of CFU's through and during activities
- To establish the effectiveness of MedicCleanAir® Mobile Hepa Units
Test-Procedure:
- CFU's taken without activities
- CFU's taken during regular day-activities = 10 - 15 operations / day
- Air-samples taken by BIAP sampler - 1 meter from operating table
- Air-samples without MedicCleanAir® as from September 2003
- Air-samples taken with MedicCleanAir® from 12 - 19 January 2004
MedicCleanAir® installations:
| regular conditions | with MedicCleanAir® | |
| no activities | range 6 - 8 | not measured |
| with activities | range 105 - 107 | 3 - 6 |
Conclusion:
- CFU's develop through and during activities
- MedicCleanAir® decrease CFU's and thus the risk of infections by over 95 %.
Report Institut Pasteur - Lille France
for testing in University Hospital in Brussels Belgium
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Situation and objective
The hospital department was newly equipped with HVAC-systems with hepa filtration that eventually did not perform the air quality needed for the purpose of the department.
The objective of the tests was not only to determine the efficiency of the MedicCleanAir® Mobile Hepa Units in relation to 'competitors', but also the time laps within the MedicCleanAir® Mobile Hepa Units were capable to 'clean' a patient's room.
Test organisation
The Pasteur-organisation is THE organisation in France in relation to trustworthy testing of Mobile Hepa Units for medical facilities
Results
MedicCleanAir® Mobile Hepa Units are able to reduce the contamination of a room with size 3.46 x 4.70 x 2.70 height meters within 7 minutes when put at level 2. Level 2 was the level recommended by the manufacturer, although the Units can be put at level 4 which is 2x the capacity of level 2.
Drawing:
Conclusion:
MedicCleanAir® Mobile Hepa Units are able to reduce the contamination within 7 minutes and keep it at that level at all times.
MedicCleanAir® Mobile Hepa Units were implemented in 30 isolation rooms.
University of Leuven Belgium 2006 - BIOSYST-MebioS: Airflow and Velocity
Objective
To determine the air currents together with the velocity and time lap during which the air of a patient's room is purified.
Test Organisation
The department BIOSYST-MebioS is THE test organisation for airflow simulations within a certain area. These can be patient's room, O.T., large ICU, etc.
Technical features
Patient room of D 4 mtr x L 5 mtr x H 2.8 mtr. MedicCleanAir® Pro Mobile Hepa Unit operational on level 2. (120m³/hour)
Drawing
Low velocity clean air supply on the bed:
(Ref. Study 2006 - Katholieke Universiteit Leuven - BIOSYST-MeBioS)
Low velocity clean air supply on the bed (head end):
(Ref. Study 2006 - Katholieke Universiteit Leuven - BIOSYST-MeBioS)
Conclusion:
Every corner of the room is being supplied by Hepa filtered air within every 11 minutes - MedicCleanAir® Pro Mobile Hepa Unit is operational on level 2 -. The velocity of the air is to be considered as comfortable to very comfortable. When put at level 4 (critical situations e.g. TBC), every place in the room will be supplied with hepa filtered air within 5 minutes.
Scientific Study by VITO - Vlaamse Instelling voor Technologisch Onderzoek, Belgium - 2000
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Test details:
Room 3 x 5 x 3 metres = 45 M³
A certain concentration of particles were blown in to the room to simulate airborne contamination - see start test period -
Objective:
To determine if the MedicCleanAir® Mobile Hepa Unit is capable of reducing the amount of contamination, and To determine in the best possible manner in which time lap the MedicCleanAir® Mobile Hepa Unit is capable to do that.
This organisation has tested MedicCleanAir® Mobile Hepa Units and have come to the following conclusion:
The MedicCleanAir® Mobile Hepa Unit was able to reduce the contamination of a room with size 3 x 5 x 3 meters height within maximum 30 minutes with more than 95%.
Drawing:
Room - 3 x 5 x 3 = 45 M3
Testperiod 28.01.2000 / 31.01.2000
Summary V.I.T.O. - report : 2000/MIM/R/7 - MedicCleanAir® - nr. 991351
MedicCleanAIr® Efficiency on regular Indoor Air / all particle sizes / working conditions
